Sin embargo, y excepto en los poco frecuentes casos y despus de que esta sntesis est completa, el cuerpo humano tiene la capacidad de convertir cualquier forma de B 12 en una forma activa, por medio de la eliminacin enzimtica de ciertos grupos prostticos de qumicos desde el tomo de cobalto y su posterior sustitucin por otros grupos
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A meta-analysis of 16 clinical trials (N=6,276) did not find a significant effect of vitamin supplementation on depressive symptoms.38 However, a review of five clinical trials (N=6,507) by da Silva and colleagues found that supplementation with folic acid, vitamin B6, and vitamin B12 was effective in preventing depression in patients recovering from stroke.39 Supplementation with folic acid, vitamin B6, and vitamin B12 may improve symptoms of depression and bipolar disorder among patients with these disorders by increasing the absorption and utilization of mood-stabilizing medications.35 Hyperhomocysteinemia is also associated with an increased risk of schizophrenia
In each of these, the "problem" of internal cleavage is the design feature
Using the wrong solvent or handling poorly can lead to cloudiness, precipitation, aggregation, or loss of potency
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